Recombinant Human CD19 Protein (ECD, FITC conjugated, His Tag)

概述

产品介绍

Cat No. CD19-PH1108

库存：现货

Size

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产品介绍

内毒素

Please contact us for more information.

生物活性

Testing in progress

蛋白构建

A DNA sequence encoding the Human CD19 (NP_001171569.1) (Met1-Lys291) was expressed with a polyhistidine tag at the C-terminus, are conjugated with FITC under optimum conditions.

表达宿主

HEK293 Stable Cells

种属

Human

预测 N 端

Pro 20

分子量

The recombinant Human CD19 consists of 283 amino acids and predicts a molecular mass of 31.56 kDa.

缓冲液

Supplied as sterile PBS 0.5% BSA, 0.03% Proclin 300.
Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.

运输方式

Liquid. It is shipped out with blue ice.

稳定性 & 储存条件

Store at 4℃ and protect it from prolonged exposure to light for up to 6 months from date of receipt. DO NOT FREEZE!

复溶

To find reconstitution info, click on 'COA' at the top of the page, enter the lot number and product size for the lot-specific COA.

Recombinant Human CD19 Protein (ECD, FITC conjugated, His Tag): 别称

B4 Protein, Human; CVID3 Protein, Human

CD19 背景信息

The cluster of differentiation (CD) system is commonly used as cell markers in Immunophenotyping. Different kinds of cells in the immune system can be identified through the surface CD molecules associating with the immune function of the cell. There are more than 320 CD unique clusters and subclusters have been identified. Some of the CD molecules serve as receptors or ligands important to the cell through initiating a signal cascade which then alter the behavior of the cell. Some CD proteins do not take part in cell signal process but have other functions such as cell adhesion. Cluster of differentiation 19 (CD19) is a member of CD system. CD19 is a cell surface molecule that assembles with the antigen receptor of B-cells. This results in a descent in the threshold for antigen receptor-dependent stimulation. A simplified view holds that the ability of B-cells to respond to the various antigens in a specific and sensitive manner is achieved in the presence of low-affinity antigen receptors. CD19 primarily acts as a B-cell co-receptor in conjunction with CD21 and CD81. The formation of the receptor complex is induced by antigen and CD19, induced by exogenous antigen, has been found cytoplasmic tail phosphorylated and bind to sIg.

全称

CD19 molecule

研究领域

Cancer Drug Targets

相关通路图

B Cell Receptor Signaling Pathway

参考文献

Zola H, et al. (2007) CD molecules 2006-human cell differentiation molecules. J Immunol Methods. 318 (1-2): 1-5.
Ho IC, et al. (2009) GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation. Nat Rev Immunol. 9 (2): 125-35.
Matesanz-Isabel J, et al. (2011) New B-cell CD molecules. Immunology Letters.134 (2): 104-12.
Carter RH, et al. (1992) CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 256 (5053): 105-7.