CD20 (membrane-spanning 4-domains,
subfamily A, member 1), also known as MS4A1, is a member of the
membrane-spanning 4A gene family. Members of this nascent protein family
are characterized by common structural features and similar intron/exon
splice boundaries and display unique expression patterns among
hematopoietic cells and nonlymphoid tissues. CD20 / MS4A1 is expressed
in all stages of B cell development except the first and last. CD20 /
MS4A1 is present from pre-pre B cells through memory cells, but not on
either pro-B cells or plasma cells. It is a B-lymphocyte surface
molecule that plays a role in the development and differentiation of
B-cells into plasma cells. CD20 / MS4A1may be involved in the regulation
of B-cell activation and proliferation. Defects in CD20 / MS4A1 are the
cause of immunodeficiency common variable type 5(CVID5). CVID5 is a
primary immunodeficiency characterized by antibody deficiency,
hypogammaglobulinemia, recurrent bacterial infections, and an inability
to mount an antibody response to antigen. The defect results from a
failure of B-cell differentiation and impaired secretion of
immunoglobulins; the numbers of circulating B-cells are usually in the
normal range but can be very low.
全称
membrane-spanning 4-domains, subfamily A, member 1
参考文献
Tedder TF, et al. (1988) Isolation and structure of a cDNA encoding the B1 (CD20)
cell-surface antigen of human B lymphocytes. Proc Natl Acad Sci. 85(1):
208-12.
Cragg MS, et al. (2005) The biology of CD20 and its potential as a target for mAb therapy. Curr Dir Autoimmun. 8: 140-74..
Polyak MJ, et al. (2003) A cholesterol-dependent CD20 epitope detected by the FMC7 antibody. Leukemia. 17(7): 1384-9.
